منابع مشابه
Functions of IL-17-Producing T Cells
IL-17 producers in T cell subsets have been recently identified to play protective roles against bacterial infection by inducing neutrophil infiltrations, organizing granulomas and acquired immunity. During ontogeny, T cells develop, maturate and localize at different tissues depending on V repertoires. V 1+, V 4+ and V 6+ cells are reportedly able to produce IL-17. V 6+ cells, which develop in...
متن کاملIL-23 drives pathogenic IL-17-producing CD8+ T cells.
IL-17-producing CD8(+) T cells (Tc17) appear to play a role in a range of conditions, such as autoimmunity and cancer. Thus far, Tc17 cells have been only marginally studied, resulting in a paucity of data on their biology and function. We demonstrate that Tc17 and Th17 cells share similar developmental characteristics, including the previously unknown promoting effect of IL-21 on Tc17 cell dif...
متن کاملIL-17-producing T cells can augment autoantibody-induced arthritis.
Rheumatoid arthritis is a T lymphocyte-mediated disorder, but the precise nature of T cell involvement remains unclear. In the K/BxN mouse model of inflammatory arthritis, T cells initiate disease by providing help to B cells to produce arthritogenic autoantibodies. Here, we have characterized an additional, nonhumoral role for T cells in promoting autoantibody-induced arthritis. Autoreactive K...
متن کاملIL-17-producing γδ T cells enhance bone regeneration.
Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone...
متن کاملIL-15 receptor α signaling constrains the development of IL-17-producing γδ T cells.
The development and homeostasis of γδ T cells is highly dependent on distinct cytokine networks. Here we examine the role of IL-15 and its unique receptor, IL-15Rα, in the development of IL-17-producing γδ (γδ-17) T cells. Phenotypic analysis has shown that CD44(high) γδ-17 cells express IL-15Rα and the common gamma chain (CD132), yet lack the IL-2/15Rβ chain (CD122). Surprisingly, we found an ...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2012
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-012-1163-6